N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir
BAY 57-1293
CAS: 348086-71-5
Molecular Formula: C18H18N4O3S2
N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir - Names and Identifiers
N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir - Physico-chemical Properties
| Molecular Formula | C18H18N4O3S2 |
| Molar Mass | 402.49 |
| Density | 1.396±0.06 g/cm3(Predicted) |
| Boling Point | 639.4±65.0 °C(Predicted) |
| pKa | 9.31±0.60(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | The mechanism of action was that BAY57-1293 directly inhibited the ATPase activity of the helicase-trigger complex by Virus in a dose-dependent manner. BAY 57-1293 also exhibited potent antiviral activity against acyclovir-resistant HSV mutants. BAY 57-1293 reduces Aβ caused by herpes simplex type 1 in vero cells by Virus and P-tau. |
| In vivo study | BAY57-1293 (oral) in mice and rats lethally disseminated herpes pathogenesis model (0.5 mg/kg), mouse herpes zoster-like skin disease spread model (15 mg/kg), and the mouse ocular herpes model showed strong antiviral activity. |
N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.485 ml | 12.423 ml | 24.845 ml |
| 5 mM | 0.497 ml | 2.485 ml | 4.969 ml |
| 10 mM | 0.248 ml | 1.242 ml | 2.485 ml |
| 5 mM | 0.05 ml | 0.248 ml | 0.497 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: BAY 57-1293 Visit Supplier Webpage Request for quotationCAS: 348086-71-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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